The Role of Polymorphisms in Vitamin D-Related Genes in Response to Vitamin D Supplementation.

ABSTRACT:

Background

Vitamin D deficiency represents a major healthcare problem. Vitamin D status is influenced by genetic and environmental determinants. Several observational studies have evaluated the association of single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and vitamin D levels. Nevertheless, little is known about the role of these SNPs in the response to vitamin D supplementation. We conducted an interventional study to define the association between SNPs in vitamin D-related genes and the response to vitamin D supplementation in 100 self-reported healthy women of Arab ancestry for the majority.

Methods

A total of 100 healthy female subjects received a weekly oral dose of 50,000 IU vitamin D for 12 weeks. Serum vitamin D concentration and metabolic profiles

SUBMITTER: Tomei S 

PROVIDER: S-EPMC7551134 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature