Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk.

ABSTRACT: The role of sodium in hypertension remains unresolved. Although genetic factors have a significant impact on high blood pressure, studies comparing genetic susceptibility between people with low and high sodium diets are lacking. We aimed to investigate the genetic variations related to hypertension according to sodium intake habits in a large Korean population-based study. Data for a total of 57,363 participants in the Korean Genome and Epidemiology Study Health Examination were analyzed. Sodium intake was measured by a semi-quantitative food frequency questionnaire. We classified participants according to sodium intake being less than or greater than 2 g/day. We used logistic regression to test single-marker variants for genetic association with a diagnosis of hypertension, adjusting for

SUBMITTER: Kwon YJ 

PROVIDER: S-EPMC7551216 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature