Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health.

ABSTRACT: Diet and lifestyle choices contribute to obesity and liver disease. Broccoli, a brassica vegetable, may mitigate negative effects of both diet and lifestyle. Currently, there are no clinically relevant, established molecular biomarkers that reflect variability in human absorption of brassica bioactives, which may be the cause of variability/inconsistencies in health benefits in the human population. Here, we focused on the plasma metabolite profile and composition of the gut microbiome in rats, a relatively homogenous population in terms of gut microbiota, genetics, sex and diet, to determine if changes in the plasma metabolite profiles caused by dietary broccoli relate to molecular changes in liver. Our aim was to identify plasma indicators that reflect how liver health is impacted by die

SUBMITTER: Eve AA 

PROVIDER: S-EPMC7551379 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature