Transient impact of paclitaxel on mouse fertility and protective effect of gonadotropin‑releasing hormone agonist.

ABSTRACT: Paclitaxel (PXL) is a chemotherapeutic agent widely used in solid tumors. However, whether PXL causes premature ovarian insufficiency in women of reproductive age remains controversial. The aim of the present study was to answer how and for how long PXL affects fertility, and to identify the protective effect of gonadotropin‑releasing hormone agonist (GnRHa) in mice. A single dose of PXL was administered to 7‑week‑old female ICR mice. Mice were treated with GnRHa for 1 estrous cycle prior to chemotherapy, and for another following chemotherapy. On the days 1, 6, 11 and 16 following the administration of PXL, mice were assessed by ovarian histology, ovarian stimulation and mating experiment. Multiple doses of PXL were also administered to verify the duration of the gonadotoxicity of PXL. It

SUBMITTER: Ma N 

PROVIDER: S-EPMC7551385 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature