Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin.

ABSTRACT: The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administrati

SUBMITTER: Rojo MA 

PROVIDER: S-EPMC7551510 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature