Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle?

ABSTRACT: Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease-namely, on autoimmune thyroid disease-has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto's thyroiditis, Graves' disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and au

SUBMITTER: Vieira IH 

PROVIDER: S-EPMC7551884 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature