Diversity of the Genomes and Neurotoxins of Strains of <i>Clostridium botulinum</i> Group I and <i>Clostridium sporogenes</i> Associated with Foodborne, Infant and Wound Botulism.

ABSTRACT: Clostridium botulinum Group I and Clostridium sporogenes are closely related bacteria responsible for foodborne, infant and wound botulism. A comparative genomic study with 556 highly diverse strains of C. botulinum Group I and C. sporogenes (including 417 newly sequenced strains) has been carried out to characterise the genetic diversity and spread of these bacteria and their neurotoxin genes. Core genome single-nucleotide polymorphism (SNP) analysis revealed two major lineages; C. botulinum Group I (most strains possessed botulinum neurotoxin gene(s) of types A, B and/or F) and C. sporogenes (some strains possessed a type B botulinum neurotoxin gene). Both lineages contained strains responsible for foodborne, infant and wound botulism. A new C

SUBMITTER: Brunt J 

PROVIDER: S-EPMC7551954 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature