Targeting aberrant expression of Notch-1 in ALDH⁺ cancer stem cells in breast cancer.

ABSTRACT: We have previously reported that high aldehyde dehydrogenase (ALDH) enzyme activity in breast cancer cells results in breast cancer stem cell (BCSC) properties by upregualting Notch-1 and epithelial mesenchymal markers. This results in chemoresistance in breast cancer. Here, we examined the functional and clinical significance of ALDH expression by measuring the ALDH levels in breast cancer tissues by immunohistochemistry. There was a significantly higher ALDH expression in higher grade breast cancer tumor tissues (Grade- II and III) versus normal breast tissues. Injection of BCSC (ALDH⁺ and CD44⁺ /CD22^- ) cells resulted in aggressive tumor growth in athymic mice versus ALDH^- cells. The ALDH⁺ and CD44⁺ /CD22^- tumo

SUBMITTER: Pal D 

PROVIDER: S-EPMC7552110 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature