Genome-Wide Identification of RNA Editing Sites Affecting Intramuscular Fat in Pigs.

ABSTRACT: Intramuscular fat (IMF) is essential for improving the palatability and flavor of meat, and it is strongly associated with human insulin resistance. RNA editing is a widespread regulating event in different tissues. Here, we investigated the global RNA editing difference of two groups of pig with different IMF contents to find the potential editing sites affecting IMF. In this research, RES-Scanner and REDItools were used to identify RNA editing sites based on the whole genome and transcriptome sequencing data of the high and low groups composed of three full-sib pairs with opposite IMF phenotypes. A total of 295 RNA editing sites were investigated in the longissimus dorsi muscle, and 90.17% of these sites caused A to G conversion. After annotation, most editing sites were located in nonco

SUBMITTER: Wang L 

PROVIDER: S-EPMC7552122 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature