Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian.

ABSTRACT:

Background

Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better understanding of disease risk than using a single gene variant approach. Furthermore, studies have found that the effect of SNPs on cardiometabolic traits can be influenced by lifestyle factors, highlighting the importance of analysing gene-lifestyle interactions.

Aims

In the present study, we investigated the association of 15 gene variants with cardiometabolic traits and examined whether these associations were modified by lifestyle factors such as dietary intake and physical activity.

Methods

The study included 110 Minangkabau women [aged 25-60 years and b

SUBMITTER: Alsulami S 

PROVIDER: S-EPMC7552350 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature