Postpartum plasma metabolomic profile among women with preeclampsia and preterm delivery: implications for long-term health.

ABSTRACT:

Background

Preeclampsia and preterm delivery (PTD) are believed to affect women's long-term health including cardiovascular disease (CVD), but the biological underpinnings are largely unknown. We aimed to test whether maternal postpartum metabolomic profiles, especially CVD-related metabolites, varied according to PTD subtypes with and without preeclampsia, in a US urban, low-income multi-ethnic population.

Methods

This study, from the Boston Birth Cohort, included 980 women with term delivery, 79 with medically indicated PTD (mPTD) and preeclampsia, 52 with mPTD only, and 219 with spontaneous PTD (sPTD). Metabolomic profiling in postpartum plasma was conducted by liquid chromatography-mass spectrometry. Linear regression models were used to assess the associations of each m

SUBMITTER: Hong X 

PROVIDER: S-EPMC7552364 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature