Pretreatment with atorvastatin ameliorates cobra venom factor-induced acute lung inflammation in mice.

ABSTRACT:

Background

The complement system plays a critical role as the pathogenic factor in the models of acute lung injury due to various causes. Cobra venom factor (CVF) is a commonly used complement research tool. The CVF can cause acute inflammation in the lung by producing complement activation components. Atorvastatin (ATR) is a 3-hydroxy-3-methylglutaryl coenzyme A inhibitor approved for control of plasma cholesterol levels. This inhibitor can reduce the acute pulmonary inflammatory response. However, the ability of ATR in treating acute lung inflammation caused by complement activation is still unknown. Therefore, we investigated the effect of ATR on lung inflammation in mice induced by activation of the complement alternative pathway in this study.

Methods

ATR (10 mg/kg/day

SUBMITTER: Guo J 

PROVIDER: S-EPMC7552367 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature