Comparative genomics and community curation further improve gene annotations in the nematode Pristionchus pacificus.

ABSTRACT:

Background

Nematode model organisms such as Caenorhabditis elegans and Pristionchus pacificus are powerful systems for studying the evolution of gene function at a mechanistic level. However, the identification of P. pacificus orthologs of candidate genes known from C. elegans is complicated by the discrepancy in the quality of gene annotations, a common problem in nematode and invertebrate genomics.

Results

Here, we combine comparative genomic screens for suspicious gene models with community-based curation to further improve the quality of gene annotations in P. pacificus. We extend previous curations of one-to-one orthologs to larger gene families and also orphan genes. Cross-species comparisons of protein lengths, screens for atypical domain combinations and species-spec

SUBMITTER: Athanasouli M 

PROVIDER: S-EPMC7552371 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature