Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.

ABSTRACT:

Background

Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients.

Methods

187 primary skull base chordoma patients between January 2008 and September 2014 were enrolled in this retrospective study. The optimal cut-off values were determined by X-tile software, and the correlations between PLT, MPV, PDW and clinicopathological features were further analysed. Kaplan-Meier curve and Cox regression analysis were used for survival analysi

SUBMITTER: Li M 

PROVIDER: S-EPMC7552483 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature