MethHaplo: combining allele-specific DNA methylation and SNPs for haplotype region identification.

ABSTRACT:

Background

DNA methylation is an important epigenetic modification that plays a critical role in most eukaryotic organisms. Parental alleles in haploid genomes may exhibit different methylation patterns, which can lead to different phenotypes and even different therapeutic and drug responses to diseases. However, to our knowledge, no software is available for the identification of DNA methylation haplotype regions with combined allele-specific DNA methylation, single nucleotide polymorphisms (SNPs) and high-throughput chromosome conformation capture (Hi-C) data.

Results

In this paper, we developed a new method, MethHaplo, that identify DNA methylation haplotype regions with allele-specific DNA methylation and SNPs from whole-genome bisulfite sequencing (WGBS) data. Our resul

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC7552496 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature