The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population.

ABSTRACT:

Backgrounds

Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. This study aimed to observe the relationship between CYP1A1 and CYP1A2 variants and stroke risk in the Chinese population.

Methods

Agena MassARRAY Assay was used to genotype four single nucleotide polymorphisms (SNPs) in 477 cases and 480 controls. The chi-square test and logistic-regression analysis were used to explore the relationship between CYP1A1 and CYP1A2 variants and stroke risk.

Results

Individuals with CYP1A2 rs762551 C was associated with a lower risk of stroke than that of allele A. Age stratification analysis showed that rs762551 was only

SUBMITTER: Mao Y 

PROVIDER: S-EPMC7552501 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature