Epigenomic landscape of enhancer elements during Hydra head organizer formation.

ABSTRACT:

Background

Axis patterning during development is accompanied by large-scale gene expression changes. These are brought about by changes in the histone modifications leading to dynamic alterations in chromatin architecture. The cis regulatory DNA elements also play an important role towards modulating gene expression in a context-dependent manner. Hydra belongs to the phylum Cnidaria where the first asymmetry in the body plan was observed and the oral-aboral axis originated. Wnt signaling has been shown to determine the head organizer function in the basal metazoan Hydra.

Results

To gain insights into the evolution of cis regulatory elements and associated chromatin signatures, we ectopically activated the Wnt signaling pathway in Hydra and monitored the genome-wide alteratio

SUBMITTER: Reddy PC 

PROVIDER: S-EPMC7552563 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature