Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption.

ABSTRACT: Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap f

SUBMITTER: Allwardt V 

PROVIDER: S-EPMC7552662 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature