Behavioral Phenotyping for Down Syndrome in Mice.

ABSTRACT: Down syndrome (DS) is the most frequent genetic cause of intellectual disability, characterized by alterations in different behavioral symptom domains: neurodevelopment, motor behavior, and cognition. As mouse models have the potential to generate data regarding the neurological basis for the specific behavioral profile of DS, and may indicate pharmacological treatments with the potential to affect their behavioral phenotype, it is important to be able to assess disease-relevant behavioral traits in animal models in order to provide biological plausibility to the potential findings. The field is at a juncture that requires assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this article, behavioral tests are described that are relevant to

SUBMITTER: Roper RJ 

PROVIDER: S-EPMC7552827 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature