Antipsychotic Withdrawal Symptoms: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Avoiding withdrawal symptoms following antipsychotic discontinuation is an important factor when planning a safe therapy. We performed a systematic review and meta-analysis concerning occurrence of withdrawal symptoms after discontinuation of antipsychotics.

Data sources

We searched the databases CENTRAL, Pubmed, and EMBASE with no restriction to the beginning of the searched time period and until October 1, 2019 (PROSPERO registration no. CRD42019119148).

Study selection

Of the 18,043 screened studies, controlled and cohort trials that assessed withdrawal symptoms after discontinuation of oral antipsychotics were included in the random-effects model. Studies that did not implement placebo substitution were excluded from analyses. The primary outcome was the

SUBMITTER: Brandt L 

PROVIDER: S-EPMC7552943 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature