Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212.

ABSTRACT: In the past decade, several groups have reported that microRNAs (miRNAs) can participate in the regulation of tau protein at different levels, including its expression, alternative splicing, phosphorylation, and aggregation. These observations are significant, since the abnormal regulation and deposition of tau is associated with nearly 30 neurodegenerative disorders. Interestingly, miRNA profiles go awry in tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and frontotemporal dementia. Understanding the role and impact of miRNAs on tau biology could therefore provide important insights into disease risk, diagnostics, and perhaps therapeutics. In this Perspective article, we discuss recent advances in miRNA research related to tau. While proof-of-principle studies hol

SUBMITTER: Boscher E 

PROVIDER: S-EPMC7553085 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature