Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum-induced colorectal tumourigenesis.

ABSTRACT:

Background

The effect of metformin on gut microbiota has been reported, but whether metformin can suppress colorectal cancer (CRC) by affecting gut microbiota composition and rescue F. nucleatum-induced tumourigenicity remains unclear.

Methods

To identify microbiota associated with both CRC occurrence and metformin treatment, first, we reanalyzed the gut microbiome of our previous data on two human cohorts of normal and CRC individuals. Subsequently, we summarized microbiota altered by metformin from published literatures. Several taxa, including Fusobacterium, were associated with both CRC occurrence and metformin treatment. We investigated the effect of metformin on APC^Min/+ mice given with or without F. nucleatum. 16S rRNA gene sequencing was performed.

Find

SUBMITTER: Huang X 

PROVIDER: S-EPMC7553239 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature