Characterization of adult patients with IgG subclass deficiency and subnormal IgG2.

ABSTRACT:

Background

Adults with IgG subclass deficiency (IgGSD) with subnormal IgG2 are inadequately characterized.

Methods

We retrospectively analyzed observations in unrelated adults with IgGSD evaluated in a single hematology clinic (1991-2019) and selected those with subnormal serum IgG2 (<117 mg/dL (<1.2 g/L)) without corticosteroid therapy to describe: age; prevalence of women; upper/lower respiratory infection; autoimmune condition(s); atopy; other allergy; frequent or severe respiratory tract infection in first-degree relatives; IgG, IgG subclasses, IgA, and IgM; blood lymphocyte subpopulations; human leukocyte antigen (HLA)-A and -B types and haplotypes; and 23-valent pneumococcal polysaccharide vaccination (PPSV23) responses. We determined the prevalence of subnormal IgG2 a

SUBMITTER: Barton JC 

PROVIDER: S-EPMC7553271 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature