Facemask against viral respiratory infections among Hajj pilgrims: A challenging cluster-randomized trial.

ABSTRACT:

Background

In this large-scale cluster-randomized controlled trial (cRCT) we sought to assess the effectiveness of facemasks against viral respiratory infections.

Methods and results

Over three consecutive Hajj seasons (2013, 2014, 2015) pilgrims' tents in Makkah were allocated to 'facemask' or 'no facemask' group. Fifty facemasks were offered to participants in intervention tents, to be worn over four days, and none were offered to participants in control tents. All participants recorded facemask use and respiratory symptoms in health diaries. Nasal swabs were collected from the symptomatic for virus detection by reverse transcription polymerase chain reaction. Clinical symptoms and laboratory results were analyzed by 'intention- to-treat' and 'per-protocol'. A total of 768

SUBMITTER: Alfelali M 

PROVIDER: S-EPMC7553311 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature