Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study.

ABSTRACT:

Background

The 2013-16 Ebola virus disease epidemic in west Africa caused international alarm due to its rapid and extensive spread resulting in a significant death toll and social unrest within the affected region. The large number of cases provided an opportunity to study the long-term kinetics of Zaire ebolavirus-specific immune response of survivors in addition to known contacts of those infected with the virus.

Methods

In this observational cohort study, we worked with leaders of Ebola virus disease survivor associations in two regions of Guinea, Guéckédou and Coyah, to recruit survivors of Ebola virus disease, contacts from households of individuals known to have had Ebola virus disease, and individuals who were not knowingly associated with infected individuals or had

SUBMITTER: Thom R 

PROVIDER: S-EPMC7553754 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature