Ontology highlight
ABSTRACT:
SUBMITTER: Roelofs PA
PROVIDER: S-EPMC7553775 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
eLife 20200928
APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for <i>A3B</i> upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expression is activated by its mutational disruption in a reporter construct or the endogenous <i>A3B</i> gene. The same E2F site is required for <i>A3B</i> induction by polyomavirus T antigen indicatin ...[more]