Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma?

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) with ground-glass opacity (GGO) can become aggravated, but the reasons for this aggravation are not fully understood. The goal of this study was to analyze the genetic features and causes of progression of GGO LUAD.

Methods

LUAD tumor samples and normal tissues were analyzed using an Illumina HiSeq 4000 system. After the tumor mutational burden (TMB) was calculated, the identified mutations were classified as those found only in GGO LUAD, those present only in non- GGO LUAD, and those common to both tissue types. Ten high-frequency genes were selected from each domain, after which protein interaction network analysis was conducted.

Results

Overall, 227 mutations in GGO LUAD, 212 in non-GGO LUAD, and 48 that were common to both tum

SUBMITTER: Kim D 

PROVIDER: S-EPMC7553832 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature