Low dose radiation therapy for COVID-19: Effective dose and estimation of cancer risk.

ABSTRACT:

Background and purpose

The objective of this work is to evaluate the risk of carcinogenesis of low dose ionizing radiation therapy (LDRT), for treatment of immune-related pneumonia following COVID-19 infection, through the estimation of effective dose and the lifetime attributable risk of cancer (LAR).

Material and methods

LDRT treatment was planned in male and female computational phantoms. Equivalent doses in organs were estimated using both treatment planning system calculations and a peripheral dose model (based on ionization chamber measurements). Skin dose was estimated using radiochromic films. Later, effective dose and LAR were calculated following radiation protection procedures.

Results

Equivalent doses to organs per unit of prescription dose range from 10 m

SUBMITTER: Garcia-Hernandez T 

PROVIDER: S-EPMC7553901 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature