Leptin alters energy intake and fat mass but not energy expenditure in lean subjects.

ABSTRACT: Based on studies in mice, leptin was expected to decrease body weight in obese individuals. However, the majority of the obese are hyperleptinemic and do not respond to leptin treatment, suggesting the presence of leptin tolerance and questioning the role of leptin as regulator of energy balance in humans. We thus performed detailed novel measurements and analyses of samples and data from our clinical trials biobank to investigate leptin effects on mechanisms of weight regulation in lean normo- and mildly hypo-leptinemic individuals without genetic disorders. We demonstrate that short-term leptin administration alters food intake during refeeding after fasting, whereas long-term leptin treatment reduces fat mass and body weight, and transiently alters circulating free fatty acids in lean m

SUBMITTER: Chrysafi P 

PROVIDER: S-EPMC7553922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature