A novel microfluidic chip-based sperm-sorting device constructed using design of experiment method.

ABSTRACT: Microfluidics is proposed as a technique for efficient sperm sorting, to achieve the ultimate goal of resolving infertility problems in livestock industry. Our study aimed to design a microfluidic sperm-sorting device (SSD) through a high-efficacy and cost- and time-effective fabrication process, by using COMSOL Multiphysics simulation and modeling software, and the design of experiment (DOE) method. The eight factors affecting SSD performance were established. The simulation was then run, and statistically significant factors were analyzed. Minitab16 was used to optimize the design modulus factor. By setting the statistical significance at p < 0.05, the factors affecting experimental structure were analyzed. At a desirability of 97.99, the optimal parameters for the microfluidic chip were

SUBMITTER: Phiphattanaphiphop C 

PROVIDER: S-EPMC7553928 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature