Gamete-level immunogenetic incompatibility in humans-towards deeper understanding of fertilization and infertility?

ABSTRACT: Human leukocyte antigen (HLA) immune genes play an important role in partner selection, but it has remained unclear if nonrandom pairing with respect to parental HLA genes could occur at the level of the gametes. We tested this possibility by investigating whether the sperm fertilization competence in humans is dependent on HLA genotype combination of the partners. We conducted a full-factorial experiment, in which the sperm physiological preparation for fertilization among multiple males was studied in the presence of follicular fluid (oocyte surrounding bioactive liquid) of several females. All the studied sperm pre-fertilization physiological parameters (motility, hyperactivation, acrosome reaction, and viability) were strongly dependent on male-female combination. In other words, folli

SUBMITTER: Jokiniemi A 

PROVIDER: S-EPMC7553942 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature