Imaging Cortical Dopamine Transmission in Cocaine Dependence: A [¹¹C]FLB 457-Amphetamine Positron Emission Tomography Study.

ABSTRACT:

Background

Positron emission tomography studies have demonstrated less dopamine D_2/3 receptor availability and blunted psychostimulant-induced dopamine release in cocaine-dependent subjects (CDSs). No studies in CDSs have reported the in vivo status of D_2/3 and dopamine release in the cortex. Basic and functional imaging studies suggest a role for prefrontal cortical dopaminergic abnormalities in impaired executive function and relapse in cocaine dependence. We used [¹¹C]FLB 457 positron emission tomography and amphetamine to measure cortical D_2/3 receptors and dopamine release in CDSs.

Methods

[¹¹C]FLB 457 and positron emission tomography were used to measure D_2/3 receptor binding potential in cortical region

SUBMITTER: Narendran R 

PROVIDER: S-EPMC7554061 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature