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Esophagogastric Junction Opening Parameters Are Consistently Abnormal in Untreated Achalasia.

ABSTRACT: Achalasia is a disorder of impaired lower esophageal sphincter (LES) relaxation and failed peristalsis traditionally characterized by manometry.1 As impaired LES relaxation is a mechanism of reduced esophagogastric junction (EGJ) opening, abnormally reduced EGJ distensibility assessed with functional luminal imaging probe (FLIP) was reported among patients with untreated achalasia.2-5 Therefore, we aimed to describe the performance characteristics of EGJ opening parameters on FLIP panometry among a large cohort of treatment-naïve achalasia patients.

SUBMITTER: Rooney KP 

PROVIDER: S-EPMC7554071 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Esophagogastric Junction Opening Parameters Are Consistently Abnormal in Untreated Achalasia.

Rooney Katharine P KP   Baumann Alexandra J AJ   Donnan Erica E   Kou Wenjun W   Triggs Joseph R JR   Prescott Jacqueline J   Decorrevont Alex A   Dorian Emily E   Kahrilas Peter J PJ   Pandolfino John E JE   Carlson Dustin A DA  

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20200411 5

Achalasia is a disorder of impaired lower esophageal sphincter (LES) relaxation and failed peristalsis traditionally characterized by manometry.<sup>1</sup> As impaired LES relaxation is a mechanism of reduced esophagogastric junction (EGJ) opening, abnormally reduced EGJ distensibility assessed with functional luminal imaging probe (FLIP) was reported among patients with untreated achalasia.<sup>2-5</sup> Therefore, we aimed to describe the performance characteristics of EGJ opening parameters  ...[more]

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