Optimizing autologous bone contribution to implant osseointegration.

ABSTRACT:

Background

Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional drills or bone scrapers. Additionally, we tested whether the osteogenic potential of bone chips could be further improved by exposure to a Wnt signaling (WNT) therapeutic.

Methods

Osteotomies were prepared in fresh rat maxillary first molar extraction sockets using a conventional drill or a new osseo-shaping instrument; titanium alloy implants were placed immediately thereafter. Using molecular/cellular and histologic analyses, the fates of the resulting bone chips were analyzed. To test whether increasing WNT signal

SUBMITTER: Coyac BR 

PROVIDER: S-EPMC7554098 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature