The Mouse Claustrum Is Required for Optimal Behavioral Performance Under High Cognitive Demand.

ABSTRACT:

Background

To achieve goals, organisms are often faced with complex tasks that require enhanced control of cognitive faculties for optimal performance. However, the neural circuit mechanisms underlying this ability are unclear. The claustrum is proposed to mediate a variety of functions ranging from sensory binding to cognitive control of action, but direct functional assessments of this telencephalic nucleus are lacking.

Methods

Here, we employed the Gnb4 (guanine nucleotide-binding subunit beta-4) cre driver line in mice to selectively monitor and manipulate claustrum projection neurons during 1-choice versus 5-choice serial reaction time task performance.

Results

Using fiber photometry, we found elevated claustrum activity prior to an expected cue during correct pe

SUBMITTER: White MG 

PROVIDER: S-EPMC7554117 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature