Psychiatric trajectories across adolescence in perinatally HIV-exposed youth: the role of HIV infection and associations with viral load.

ABSTRACT:

Objective

Identify factors associated with trajectories of psychiatric disorder among 340 adolescents and young adults (AYA) living with perinatal HIV infection (PHIV) and perinatal HIV-exposure but not infection (PHEU).

Design

Longitudinal cohort study of AYA in New York City, 9-16 years at enrollment.

Methods

We used multivariate longitudinal latent class analysis to identify trajectories of psychiatric disorder, and logistic regression to examine predictors of trajectories (e.g. PHIV status) and associations between trajectories and viremia in young adulthood (AYA with PHIV only).

Results

Among all AYA, we identified three psychiatric trajectories: relatively 'low disorder' (63%), 'consistent anxiety' (26%), and 'escalating comorbidity' (11%). Compared with

SUBMITTER: Nguyen N 

PROVIDER: S-EPMC7554128 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature