Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease.

ABSTRACT:

Introduction

Imaging neurovascular disturbances in Parkinson's disease (PD) is an excellent measure of disease severity. Indeed, a disease-specific regional pattern of abnormal metabolism has been identified using positron emission tomography. Only a handful of studies, however, have applied perfusion MRI to detect this disease pattern. Our goal was to replicate the evaluation of a PD-related perfusion pattern using scaled subprofile modeling/principal component analysis (SSM-PCA).

Methods

We applied arterial spin labeling (ASL) MRI for this purpose. Uniquely, we assessed this pattern separately in PD individuals ON and OFF dopamine medications. We further compared the existence of these patterns and their strength in each individual with their Movement Disorder Society-Unif

SUBMITTER: Rane S 

PROVIDER: S-EPMC7554132 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature