Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles.

ABSTRACT:

Rationale

HDL (high-density lipoprotein) may be cardioprotective because it accepts cholesterol from macrophages via the cholesterol transport proteins ABCA1 (ATP-binding cassette transporter A1) and ABCG1 (ATP-binding cassette transporter G1). The ABCA1-specific cellular cholesterol efflux capacity (ABCA1 CEC) of HDL strongly and negatively associates with cardiovascular disease risk, but how diabetes mellitus impacts that step is unclear.

Objective

To test the hypothesis that HDL's cholesterol efflux capacity is impaired in subjects with type 2 diabetes mellitus.

Methods and results

We performed a case-control study with 19 subjects with type 2 diabetes mellitus and 20 control subjects. Three sizes of HDL particles, small HDL, medium HDL, and large HDL, were isolate

SUBMITTER: He Y 

PROVIDER: S-EPMC7554159 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature