The maternal microbiome modulates fetal neurodevelopment in mice.

ABSTRACT: 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as infection¹, altered diet² and stress³ during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring⁴. However, it is unclear whether the maternal gut microbiome influences neurodevelopment during critical prenatal periods and in the absence of environmental challenges. Here we investigate how depletion and selective reconstitution of the maternal gut microbiome influences fetal neurodevelopment in mice. Embryos from antibiotic-treated and germ-free dams exhibited reduced brain expression of genes related to axonogenesis, deficient thalamocortical axons and impaired outgrowth of thalamic axons in response to cell-e

SUBMITTER: Vuong HE 

PROVIDER: S-EPMC7554197 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature