Lateralized evoked responses in parietal cortex demonstrate visual short-term memory deficits in first-episode schizophrenia.

ABSTRACT: Working memory dysfunction may be central to neurocognitive deficits in schizophrenia. Maintenance of visual information in working memory, or visual short-term memory (vSTM), is linked to general cognitive dysfunction and predicts functional outcome. Lateralized change-detection tasks afford investigation of the contralateral delay activity (CDA), a useful tool for investigating vSTM dysfunction. Previous work suggests "hyperfocusing" of attention in schizophrenia, such that CDA is increased when a single item is maintained in vSTM but reduced for multiple items. If observed early in the disease, vSTM dysfunction may be a key feature of schizophrenia or target for intervention. We investigated CDA during lateralized vSTM of one versus three items using sensor-level electroencephalography

SUBMITTER: Coffman BA 

PROVIDER: S-EPMC7554220 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature