Inflammasomes: a preclinical assessment of targeting in atherosclerosis.

ABSTRACT:

Introduction

Inflammasomes are central to atherosclerotic vascular dysfunction with regulatory effects on inflammation, immune modulation, and lipid metabolism. The NLRP3 inflammasome is a critical catalyst for atherogenesis thus highlighting its importance in understanding the pathophysiology of atherosclerosis and for the identification of novel therapeutic targets and biomarkers for the treatment of cardiovascular disease.

Areas covered

This review includes an overview of macrophage lipid metabolism and the role of NLRP3 inflammasome activity in cardiovascular inflammation and atherosclerosis. We highlight key activators, signal transducers and major regulatory components that are being considered as putative therapeutic targets for inhibition of NLRP3-mediated cardiovasc

SUBMITTER: Stitham J 

PROVIDER: S-EPMC7554266 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature