Electrolyte-based calculation of fluid shifts after infusing 0.9% saline in severe hyperglycemia.

ABSTRACT:

Background

Early treatment of severe hyperglycemia involves large shifts of body fluids that entail a risk of hemodynamic instability. We studied the feasibility of applying a new electrolyte equation that estimates the degree of volume depletion and the distribution of infused 0.9% saline in this setting.

Methods

The new equation was applied to plasma and urinary concentrations of sodium and chloride measured before and 30 min after a 30-min infusion of 1 L of 0.9% saline on two consecutive days in 14 patients with severe hyperglycemia (mean age 50 years). The extracellular fluid (ECF) volume was also estimated based on the volume dilution kinetics of chloride.

Results

On day 1, the baseline ECF volume amounted to 11.5 L. The saline infusion expanded the ECF space by

SUBMITTER: Svensson R 

PROVIDER: S-EPMC7554273 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature