Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta-analysis.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a metabolic disorder with growing prevalence and increasing economic burden. Based on the role of genetics and epigenetic factors on T2DM, we aimed to carry a systematic review and meta-analysis for all miRNA gene polymorphisms and risk of T2DM.

Materials and methods

A computerized literature search was carried out on PubMed, Web of Science, Scopus, Embase, as well as references of relevant review/meta-analysis. Key search terms were "Diabetes Mellitus, Type 2," "MicroRNAs," and "Polymorphism, Single Nucleotide." All types of observational studies from January 1, 1992, to November 30, 2019, were included, without language restriction. Data analysis was performed using R programming language (3.5.2). Level of heterogeneity was obt

SUBMITTER: Gholami M 

PROVIDER: S-EPMC7554443 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature