Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth.

ABSTRACT:

Aim

To determine whether variability in diffusion MRI (dMRI) white matter tract metrics, obtained in a cohort of preterm infants prior to neonatal hospital discharge, would be associated with language outcomes at age 2 years, after consideration of age at scan and number of major neonatal complications.

Method

30 children, gestational age 28.9 (2.4) weeks, underwent dMRI at mean post menstrual age 36.4 (1.4) weeks and language assessment with the Bayley Scales of Infant Development-III at mean age 22.2 (1.7) months chronological age. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for 5 white matter tracts. Hierarchical linear regression assessed associations between tract FA, moderating variables, and language outcomes.

Results

FA of the lef

SUBMITTER: Dubner SE 

PROVIDER: S-EPMC7554644 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature