Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients.

ABSTRACT: Cancer has adverse effects on male reproductive health. Conventional semen analysis does not explain the molecular changes in the spermatozoa of cancer patients. Currently, proteomics is being widely used to identify the fertility-associated molecular pathways affected in spermatozoa. The objective of this study was to evaluate the sperm proteome of patients with various types of cancer. Cryopreserved semen samples from patients (testicular cancer, n = 40; Hodgkin's disease, n = 32; lymphoma, n = 20; leukemia, n = 17) before starting therapy were used for proteomic analysis, while samples from fertile donors (n = 19) were included as controls. The proteomic profiling of sperm was carried out by liquid chromatography-tandem mass spectrometry, and different

SUBMITTER: Panner Selvam MK 

PROVIDER: S-EPMC7554694 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature