From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases.

ABSTRACT: Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions that slowly deteriorate quality of life and for which our diagnostic power is high, but our knowledge on etiology and/or effective treatment options still contains important gaps. In the context of day-to-day practice, clinical and preclinical studies, clinicians and basic researchers team up and continuously strive to increase insights into lung disease progression, diagnostic and treatment options. To unravel disease processes and to test novel therapeutic approaches, investigators typically rely on end-stage procedures such as serum analysis, cyto-/chemokine profiles and selective tissue histology from animal models. These techniques are useful but provide only a snapshot of dis

SUBMITTER: Tielemans B 

PROVIDER: S-EPMC7554749 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature