The Pathopharmacological Interplay between Vanadium and Iron in Parkinson's Disease Models.

ABSTRACT: Parkinson's disease (PD) pathology is characterised by distinct types of cellular defects, notably associated with oxidative damage and mitochondria dysfunction, leading to the selective loss of dopaminergic neurons in the brain's substantia nigra pars compacta (SNpc). Exposure to some environmental toxicants and heavy metals has been associated with PD pathogenesis. Raised iron levels have also been consistently observed in the nigrostriatal pathway of PD cases. This study explored, for the first time, the effects of an exogenous environmental heavy metal (vanadium) and its interaction with iron, focusing on the subtoxic effects of these metals on PD-like oxidative stress phenotypes in Catecholaminergic a-differentiated (CAD) cells and PTEN-induced kinase 1 (PINK-1)^B9Drosoph

SUBMITTER: Ohiomokhare S 

PROVIDER: S-EPMC7554808 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature