Molecular Changes in Tissue Proteome during Prostate Cancer Development: Proof-of-Principle Investigation.

ABSTRACT: (1) Background: Prostate cancer (PCa) is characterized by high heterogeneity. The aim of this study was to investigate molecular alterations underlying PCa development based on proteomics data. (2) Methods: Liquid chromatography coupled to tandem mass spectrometry was conducted for 22 fresh-frozen tissue specimens from patients with benign prostatic hyperplasia (BPH, n = 5) and PCa (n = 17). Mann Whitney test was used to define significant differences between the two groups. Association of protein abundance with PCa progression was evaluated using Spearman correlation, followed by verification through investigating the Prostate Cancer Transcriptome Atlas. Functional enrichment and interactome analysis were carried out using Metascape and String. (3) Results: Proteomics analysis identified

SUBMITTER: Latosinska A 

PROVIDER: S-EPMC7554904 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature