(E)-Piplartine Isolated from Piper pseudoarboreum, a Lead Compound against Leishmaniasis.

ABSTRACT: The current therapies of leishmaniasis, the second most widespread neglected tropical disease, have limited effectiveness and toxic side effects. In this regard, natural products play an important role in overcoming the current need for new leishmanicidal agents. The present study reports a bioassay-guided fractionation of the ethanolic extract of leaves of Piper pseudoarboreum against four species of Leishmania spp. promastigote forms, which afforded six known alkamides (1-6). Their structures were established on the basis of spectroscopic and spectrometric analysis. Compounds 2 and 3 were identified as the most promising ones, displaying higher potency against Leishmania spp. promastigotes (IC50 values ranging from 1.6 to 3.8 µM) and amastigotes of L. amazonensis (IC50 values ranging fro

SUBMITTER: Ticona JC 

PROVIDER: S-EPMC7554920 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature