Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease.

ABSTRACT: Background: The prevalence of chronic kidney disease is increased in patients with cystic fibrosis (CF). The study of urinary exosomal proteins might provide insight into the pathophysiology of CF kidney disease. Methods: Urine samples were collected from 19 CF patients (among those 7 were treated by cystic fibrosis transmembrane conductance regulator (CFTR) modulators), and 8 healthy subjects. Urine exosomal protein content was determined by high resolution mass spectrometry. Results: A heatmap of the differentially expressed proteins in urinary exosomes showed a clear separation between control and CF patients. Seventeen proteins were upregulated in CF patients (including epidermal growth factor receptor (EGFR); proteasome subunit beta type-6, transglutaminases, caspase 14) and 118 were

SUBMITTER: Gauthier S 

PROVIDER: S-EPMC7554933 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature